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Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme

Author(s) : Bresalier R., Chatterjee N., Flood A., Hayes RB., Kulldorff M., Peters U., Schatzkin A., Sinha R., Subar AF., Weissfeld JL., Ziegler RG.
Date : May, 2003
Source(s) : Lancet #361:9368 p1491-1495
Adresse : " PETERS U,NCI,DIV CANC EPIDEMIOL & GENET NUTR EPIDEMIOL BRANCH NIH,DHHS;6129 EXECUT BLVD,EPS 3024; BETHESDA MD 20892, USA.petersu@mail.nih.gov"

Background Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial.Methods We used a 137-item food frequency questionnaire to assess the relation of fibre intake and frequency of colorectal adenoma. The study was done within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a randomised controlled trial designed to investigate methods for early detection of cancer. In our analysis, we compared fibre intake of 33 971 participants who were sigmoidoscopy-negative for polyps, with 3591 cases with at least one histologically verified adenoma in the distal large bowel (ie, descending colon, sigmoid colon, or rectum). Odds ratios were estimated by logistic regression analysis.Findings High intakes of dietary fibre were associated with a lower risk of colorectal adenoma, after adjustment for potential dietary and non-dietary risk factors. Participants in the highest quintile of dietary fibre intake had a 27% (95% Cl 14-38, P-trend=0.002) lower risk of adenoma than those in the lowest quintile. The inverse association was strongest for fibre from grains and cereals and from fruits. Risks were similar for advanced and non-advanced adenoma. Risk of rectal adenoma was not significantly associated with fibre intake.Interpretation Dietary fibre, particularly from grains, cereals, and fruits, was associated with decreased risk of distal colon adenoma.

Source : Pubmed

 

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