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Inhibition of lipid peroxidation induced by gamma-radiation and aaph in rat liver and brain mitochondria by mushrooms

Author(s) : Lakshmi B., Tilak JC., Adhikari S., Devasagayam TPA., Janardhanan KK.
Date : Feb, 2005
Source(s) : Current Science #88:3 p484-488
Adresse : Reprints: JANARDHANAN KK,AMALA CANC RES CTR,DEPT MICROBIOL; AMALA NAGAR THRISSUR 680553, INDIA. kkjanardhanan@yahoo.com Research Institutions: Amala Canc Res Ctr, Dept Microbiol, Amala Nagar 680553, Thrissur, India. Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, India. Bhabha Atom Res Ctr, Radiat Chem & Chem Dynam Div, Bombay 400085, Maharashtra, India. Discipline: MULTIDISCIPLINARY MULTIDISCIPLINARY

Exposure to radiation or 2.2'Azobis(2-amidopropane) dihydrochloride (AAPH) induces generation of reactive oxygen species (ROS) especially hydroxyl radical ((OH)-O-.) and peroxyl radical (ROO.), which are capable of inducing lipid peroxidation. Our earlier studies have demonstrated that extracts of the medicinal and edible mushrooms Ganoderma lucidum, Pleurotus florida, Pleurotus sajor-caju and Phellinus rimosus possessed significant antioxidant activity, measured as radical scavenging. In the present study, we examined the protective effect of these mushroom extracts against radiation- and AAPH-induced lipid peroxidation using rat liver and brain mitochondria as model systems. The results obtained showed that the investigated mushroom extracts significantly inhibited the formation of lipid hydroperoxide and thiobarbituric acid reactive substances, indicating membrane protective effects. The finding suggests the profound protective effect of the extracts of the fruiting bodies of G. lucidum, P.florida, P. sajor-caju and P. rimosus against lipid peroxidation by two major forms of ROS capable of inducing this type of damage in a major organelle, the mitochondria from both rat liver and brain. This observation can possibly explain the health benefits of these mushrooms.

Source : Pubmed


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