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Suppressive activity of the fruit of momordica charantia with exercise on blood glucose in type 2 diabetic mice.

Author(s) : Ishida T., Itoh Y., Iwamoto N., Kato M., Miura T.
Date : Feb, 2004
Source(s) : Biol Pharm Bull #27:2 p248-250
Adresse : Department of Clinical Nutrition, Suzuka University of Medical Science, 1000-1 Kishioka, Suzuka, Mie 510-0293, Japan. miura@suzuka-u.ac.jp

The antidiabetic activity of Momordica charantia L. (Cucurbitaceae) with exercise was investigated in KK-Ay mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of Momordica charantia L. (MC) with exercise reduced the blood glucose of KK-Ay mice 5 weeks after oral administration (p<0.001), and also significantly lowered the plasma insulin of KK-Ay mice under similar conditions (p<0.01). The blood glucose of MC with exercise is lower than that of MC only or exercise only 5 weeks after the administration. MC with exercise decreased blood glucose in a glucose tolerance test. These results suggest that MC with exercise is useful for type 2 diabetic cure.

Source : Pubmed

 

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