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Two novel cucurbitacins, neocucurbitacins A and B, from the Brazilian folk medicine "Buchinha" (Luffa operculata) and their effect on PEBP2alphaA and OCIF gene expression in a human osteoblast-like Saos-2 cell line.

Author(s) : Hakamatsuka T., Kawahara N., Kurata A., Satake M., Sekita S.
Date : Oct, 2001
Source(s) : Chemical And Pharmaceutical Bulletin #49:10 p1377-1379
Adresse : KAWAHARA N,NATL INST HLTH SCI,SETAGAYA KU;1-18-1 KAMIYOGA; TOKYO 1588501, JAPAN.kawahara@nihs.go.jp

Two novel cucurbitacins designated as neocucurbitacins A (1), possessing inhibitory activity of polyoma enhancer binding protein 2 alphaA (PEBP2 alphaA) and osteoclastogenesis-inhibitory factor (OCIF) gene expression in human osteoblast-like cells, and B (2) were isolated from the fruit of Luffa operculata. Their structures have been determined by extensive spectroscopic investigation.

Source : Pubmed

 

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