A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change.

Auteur(s) :
Martínez-González MÁ., Martinez JA., Razquin C.
Date :
Août, 2010
Source(s) :
Eur J Nutr.. #49:5 p311-9
Adresse :
Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Irunlarrea 1, 31080, Pamplona, Navarra, Spain.

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PURPOSE:
Adiponectin gene variations have been associated with obesity. There are few interventional studies analyzing this association. The aim of this study was to analyze the effects of a nutritional intervention with Mediterranean-style diet and three (-4034A/C, +45T/G, and +276 G/T) adiponectin gene variants on 3-year body weight changes in high cardiovascular risk patients.

SUBJECTS AND METHODS:
A total of 737 participants, aged 55-80 at high cardiovascular risk were assigned to a low-fat diet or to a Mediterranean-style diet (MD) groups, one with high intake of virgin olive oil (VOO) and the other with high intake of nuts. Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the -4034A/C, +45T/G, and +276 G/T polymorphisms was done.

RESULTS:
GG genotype of the +45T/G polymorphism was associated with 3-year higher body weight gain (B = 1.399; B = 0.043). TT genotype of the +276G/T polymorphism was linked to the highest 3-year body weight gain in men. Both Mediterranean diets appeared to reverse this effect (p for interaction = 0.053).

CONCLUSION:
Adiponectin gene variation appeared to be associated with 3-year body weight changes in a high cardiovascular risk population. This association may be modulated by a nutritional intervention with a Mediterranean-style diet.

Source : Pubmed
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