A lifestyle program for treated hypertensives improved health-related behaviors and cardiovascular risk factors, a randomized controlled trial

Auteur(s) :
Williams AE., Burke, V., Cutt, HE., Mansour, J., Mori, TA., Beilin LJ.
Date :
Fév, 2007
Source(s) :
JOURNAL OF CLINICAL EPIDEMIOLOGY. #60:2 p133-141
Adresse :
Addresses: Burke V (reprint author), Univ Western Australia, Royal Perth Hosp Unit, Sch Med & Pharmacol, Cardiovasc Res Ctr, Perth, WA 6847 Australia Univ Western Australia, Royal Perth Hosp Unit, Sch Med & Pharmacol, Cardiovasc Res Ctr, Perth, WA 6847 Australia W Australian Inst Med Res, Perth, WA Australia E-mail Addresses: [email protected] Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND, http://www.elsevier.com Discipline: ENVIRONMENTAL MEDICINE & PUBLIC HEALTH MEDICAL RESEARCH, GENERAL TOPICS

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OBJECTIVE:
To assess effects of a cognitively based program on health-related behaviors and cardiovascular risk factors in overweight drug-treated hypertensives.

STUDY DESIGN AND SETTING:
In a clinical trials center, volunteers, recruited by advertisement, were randomized to usual care (N=118) or to a 4-month program (N=123) incorporating weight loss; a low-sodium diet, high in fruit, vegetables, and fish; and increased physical activity. Diet, physical activity, weight, blood lipids, glucose, and insulin were measured at 4 and 16 months.

RESULTS:
Ninety-eight usual care and 106 program participants completed the 4-month assessment; 90 and 102, respectively, completed follow-up. Using intention-to-treat analysis, relative to usual care, net changes with the program at 4 months were as follows: dietary fat (-2.6% energy; P<0.001); sodium (-290mg/d; P=0.004); energy (-313mJ/d; P=0.005); fish (+2.1 serves/wk; P<0.001); vegetables (+3.0 serves/wk; P<0.001); physical activity (+37min/wk; P=0.004); weight (-2.8kg; P<0.001); waist girth (-3.1cm; P<0.001); total cholesterol (-0.2mmol/L; P=0.017); and triacylglycerols (-0.12mmol/L; P=0.002). One year later, net changes included dietary fat (-2.2% energy; P<0.001); sodium (-150mg/d; P=0.029); fish (+2.0 serves/wk; P<0.001); vegetables (+4.3 serves/wk; P<0.001); weight (-2.5kg; P=0.001); waist girth (-3.1cm; P<0.001); high-density lipoprotein cholesterol (+0.03mmol/L; P=0.031).

CONCLUSION:
Improvements in behaviors and risk factors, several maintained long term, suggest the potential for long-term benefits in hypertensives.

Source : Pubmed
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