A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women

Auteur(s) :
Stampfer MJ., Willett WC., Rosner BA., Colditz GA., Hankinson SE., Speizer FE., Chasan-taber L., Seddon JM.
Date :
Avr, 1999
Source(s) :
AMERICAN JOURNAL OF CLINICAL NUTRITION. #70:4 p509-516
Adresse :
CHASAN-TABER L,UNIV MASSACHUSETTS,SCH PUBL HLTH & HLTH SCI DEPT BIOSTAT & EPIDEMIOL;405 ARNOLD HOUSE;AMHERST,MA 01003 USALCT@schoolph.umass.edu

Sommaire de l'article

Background:
Oxidation of lens proteins plays a central role in the formation of age-related cataracts, suggesting that dietary antioxidants may play a role in prevention. However, the relation between specific antioxidants and risk of cataract remains uncertain.

Objective:
Our objective was to examine prospectively the association between carotenoid and vitamin A intakes and cataract extraction in women.

Methods:
A prospective cohere of registered female nurses aged 45-71 y and free of diagnosed cancer was followed; in 1980, 50461 were included and others were added as they became 45 y of age for a total of 77466. Information on nutrient intake was assessed by repeated administration of a food-frequency questionnaire during 12 y of follow-up.

Results:
During 761 762 person-years of follow-up, 1471 cataracts were extracted. After age, smoking, and other potential cataract risk factors were controlled for, those with the highest intake of lutein and zeaxanthin had a 22% decreased risk of cataract extraction compared with those in the lowest quintile (relative risk: 0.78; 950/0 CI: 0.63, 0.95; P for trend = 0.04). Other carotenoids (alpha-carotene, X-carotene, lycopene, and beta-cryptoxanthin), vitamin A, and retinol were not associated with cataract in multivariate analysis. Increasing frequency of intakes of spinach and kale, foods rich in lutein, was associated with a moderate decrease in risk of cataract.

Conclusions:
Lutein and zeaxanthin and foods rich in these carotenoids may decrease the risk of cataracts severe enough to require extraction.

Source : Pubmed
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