A vegetable-fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers

Auteur(s) :
Broekmans WMR., Van Den Berg H., Sebastian A., Cnubben NHP., Haenen GRMM., Roza L., Vaes WHJ., Van Den Berg R., Van VLIET.
Date :
Juin, 2001
Source(s) :
JOURNAL OF NUTRITION. #131:6 p1714-1722
Adresse :
VAN DEN BERG R,TNO NUTR & FOOD RES,DEPT NUTR PHYSIOL;UTRECHTSEWEG 48,POB 360;NL-3700 AJ ZEIST, NETHERLANDS.R.vandenBerg@voeding.tno.nl

Sommaire de l'article

The potential benefits of a high fruit and vegetable intake on the antioxidant status and on relevant biomarkers of oxidative damage to lipids, proteins and DNA and on (functional) markers of oxidative stress were evaluated. A randomized, free living, open placebo-controlled cross-over trial of 3 wk, with a 2-wk washout period between treatments, was performed in a group of 22 male smokers with a relatively low vegetable and fruit intake using a vegetable burger and fruit drink. The vegetable burger and fruit drink increased serum levels of vitamin C, alpha -carotene, beta -carotene, beta -cryptoxanthin and zeaxanthin and plasma total antioxidant capacity. However, no effects were demonstrated on any marker of oxidative damage to lipids (malondialdehyde F-2-isoprostane) proteins (carbonyls) and DNA (Comet assay) and (functional) markers of oxidative stress (reduced/oxidized glutathione ratio, glutathione-S-transferase alpha, glutathione-S-transferase pi and nuclear transcription factor-kappaB). Apparently, these increased levels of antioxidants in serum were not sufficiently high to show beneficial changes with the selected biomarkers. Alternatively, oxidative stress in male smokers with a relatively low fruit and vegetable intake might have been still too low to demonstrate a beneficial effect of antioxidants.

Source : Pubmed
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