Adherence to nutritional recommendations and subsequent cognitive performance: findings from the prospective Supplementation with Antioxidant Vitamins and Minerals 2 (SU.VI.MAX 2) study.

Auteur(s) :
Castetbon K., Kesse-Guyot E., Amieva H.
Date :
Jan, 2011
Source(s) :
Am J Clin Nutr.. #93:1 p200-10
Adresse :
SU.VI.MAX 2 Research Group Collaborators (91)Vogt L, Escande ME, Sérot JM, Vasseur E, Debray M, Hussonnois C, Iehl-Robert M, le Sommer M, Boge T, Rajaonarivo J, Jouseau J, Frison M, Gentric A, Leenaert F, Bascou B, Lemaire JP, Baptiste N, Maugourd MF, Gibelain A, Lopitaux R, Hild J, Nachar H, Soulié G, Clémenti F, Friocourt P, Sagnier A, Schiano P, Collet A, Richard D, Zandi F, Couturier P, Raynaud-Simon A, Lermite P, Alix M, Alix E, Puisieux F, Gaxatte C, Dantoine T, Livet P, Albrand G, Haond P, Ménecier P, Pinoche F, Guillaume S, Heim M, Wang A, Jeandel C, Passadori Y, Benetos A, Couturier C, Berrut G, Sacher-Huvelin S, Patouraux H, Brocker P, Guérin O, Strubel D, Dupriez F, Gauvain JB, Wolmark Y, Hanon O, Bernard Cassou B, Déjardin P, de la Fournière F, Wone F, Buj-Hardy C, Paccalin M, Placines B, Novella JL, Jouanny P, Martin F, Chassagne P, Landrin I, Girtanner C, Gonthier R, Troadec C, Dourthe C, Bonnin E, Marot JP, Rossignol S, Sebbane G, Cornu PY, Monsuez JJ, Périllat I, Ratiney R, Kaltenbach G, Rolland Y, Constans T, Coz G, Ferry M, Aquino JP, Cézard O. Unité de Recherche en Epidémiologie Nutritionnelle, U557 INSERM/U1125 Inra/Cnam/Université Paris 13, CRNH IdF, Bobigny, France. [email protected]

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BACKGROUND:
Few studies have investigated the long-term effect of overall nutritional recommendations on cognition.

OBJECTIVE:
In a French cohort of middle-aged adults, we evaluated the association between the French National Nutrition and Health Program (Program National Nutrition Santé) Guideline Score (PNNS-GS) assessed at baseline and cognitive performance evaluated 13 y later.

DESIGN:
The PNNS-GS was estimated at baseline (1994-1996) (maximum score: 15 points) in 2135 subjects in the SU.VI.MAX (Supplementation with Antioxidant Vitamins and Minerals) study. We assessed cognitive performance of subjects in 2007-2009 via a battery of 4 neuropsychologic tests that included phonemic and semantic fluency, the RI-48 (rappel indicé-48 item) cued-recall test, the trail-making test, and forward and backward digit spans. A principal components analysis was performed to account for correlations in test scores. Multivariate linear regression models or analyses of covariance were also performed.

RESULTS:
In a multivariate model, we observed a positive association between the PNNS-GS and the cued-recall test and semantic and phonemic fluency tasks, whereas no association was observed with digit spans. The principal components analysis revealed 2 factors interpreted as reflecting verbal memory and executive functioning. Better adherence to nutritional recommendations was significantly associated with the verbal memory factor (β = 0.41; 95% CI: 0.17, 0.64), whereas no association was shown with the executive functioning factor. Removing specific components from the PNNS-GS did not modify the findings.

CONCLUSION:
This study suggests that strong compliance with nutritional recommendations in midlife is associated in elderly individuals with better verbal memory, which is a cognitive domain that is particularly vulnerable to pathologic aging and Alzheimer disease.

Source : Pubmed
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