Allium vegetable intake and gastric cancer: a case-control study and meta-analysis.

Auteur(s) :
La Vecchia C., Turati F., Galeone C., Guercio V., Pelucchi C.
Date :
Sep, 2014
Source(s) :
Mol Nutr Food Res.. # p
Adresse :
Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via G. La Masa 19, 20156, Milano, Italy.

Sommaire de l'article

To provide new epidemiological data and summarize evidence on the association between allium vegetable intake and gastric cancer risk.

Data were from an Italian case-control study including 230 cases and 547 controls. Odds ratios (OR) were derived using multiple logistic regression. We combined results from all published studies using random-effect models.

In our case-control study, the ORs were 0.59 (95% confidence interval, CI, 0.25-1.41) for ?2 portions of onion/week, 0.69 (95% CI, 0.41-1.15) for high garlic intake, and 0.70 (95% CI, 0.39-1.28) for frequent use of both onion and garlic. Besides our study, 22 case-control and 4 cohort studies were included in the meta-analyses (>10000 cases). The pooled relative risks (RR) for the highest versus the lowest intake category were 0.78 (95% CI, 0.67-0.91) for allium vegetables (10 case-control and 4 cohort studies), 0.60 (95% CI, 0.47-0.76) for garlic (12 case-control studies), and 0.55 (95%CI, 0.41-0.73) for onion (13 case-control studies). The pooled RR for high allium vegetables intake from the 4 cohorts was 1.02 (95% CI, 0.88-1.18).

High allium vegetables consumption is likely to reduce gastric cancer risk. This evidence derived mainly from case-control studies. Further data from large cohorts are desirable for conclusive confirmation. This article is protected by copyright. All rights reserved.

Source : Pubmed