Chemoprevention of cancer: lessons to be learned from beta-carotene trials

Auteur(s) :
Vainio H.
Date :
Mar, 2000
Source(s) :
TOXICOLOGY LETTERS. #112 p513-517
Adresse :
"VAINIO H,KAROLINSKA INST,NATL INST ENVIRONM MED DIV HLTH RISK ASSESSMENT;POB 210;S-17177 STOCKHOLM, SWEDEN.harri.vainio@imm.ki.se "

Sommaire de l'article

Observational studies indicate a lower incidence of chronic diseases, including various cancers and cardiovascular disease, related to higher intakes of carotenoid containing foods (fruits and vegetables). Beta-carotene, one of the large number of naturally occurring carotenoids, thus appears to actively participate in health. However, recent intervention trials indicate that beta-carotene supplements are not efficacious in the prevention of cardiovascular disease and major cancers occurring in well-nourished populations. In fact, supplemental beta-carotene appears to increase, rather than to reduce, lung cancer incidence and deaths from cardiovascular disease in current smokers and in asbestos exposed workers. In order to resolve these paradoxes, we need to better understand the underlying biology, identify interactions, develop mechanistic hypotheses and test them in clinical trials in humans. Until that time, we should confine any premature enthusiasm for chemopreventive supplementation.

Source : Pubmed
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