Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis.

Auteur(s) :
Woodside JV., Cantwell MM., Cirmi S., Navarra M.
Date :
Mai, 2018
Source(s) :
Pharmacological research. #133: p187-194
Adresse :
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; Prof. Antonio Imbesi Foundation, Messina, Italy. Electronic address: scirmi@unime.it.

Sommaire de l'article

OBJECTIVE
To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx.

DESIGN
Systematic review and meta-analysis.

DATA SOURCES
Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm.

STUDY SELECTION
The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A pre-defined inclusion checklist resulted in the inclusion of articles which were (i) published in peer-reviewed scientific journals; (ii) English language; (iii) and included a measure of Citrus fruit intake and risk of oral and pharyngeal cancer. Studies were excluded if (i) preparations derived from other fruits were used, (ii) Citrus intake was combined with intake of other fruits; (iii) in vitro or animal models were used. We also excluded reviews, systematic reviews, meta-analyses, letters, personal opinions, conference abstracts and book chapters.

DATA EXTRACTION
Three reviewers independently performed the extraction of data from studies included.

RESULTS
Seventeen studies met our inclusion criteria and were included in the final review. Pooled analyses showed that those with the highest Citrus fruit intake compared to the lowest intake had a 50% reduction in risk of oral cavity and pharyngeal cancer (OR 0.50; 95% CI 0.43-0.59).

CONCLUSION
The studies included in this review and meta-analysis showed an inverse association between Citrus fruit intake and oral cancer.

Source : Pubmed
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