Combined effect of vegetable protein (soy) and soluble fiber added to a standard cholesterol-lowering diet

Auteur(s) :
Jenkins DJA., Kendall CWC., Mehling CC., Vidgen E., Connelly PW., Parker TL., Agarwal S., Cunnane SC., Furumoto E., Griffin LC., Jones PJ., Novokmet R., Raeini-sarjaz M., Rao AV., Ryan MA., Story JA.
Date :
Juin, 1999
Source(s) :
METABOLISM. #48:6 p809-816
Adresse :
Clinical Nutrition and Risk Factor Modification Center and the Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.

Sommaire de l'article

Dietary treatment of hyperlipidemia focuses on reducing saturated fat and dietary cholesterol. Other aspects of diet are not emphasized at present, despite growing evidence that a number of plant components decrease serum cholesterol. We therefore determined whether a combination of two plant components, vegetable protein and soluble fiber, further reduce serum lipids when incorporated into the currently advocated low-saturated-fat diet. Thirty-one hyperlipidemic men and women ate two 1-month low-fat (<7% of total energy from saturated fat), low-cholesterol (<80 mg cholesterol/d) metabolic diets in a randomized crossover study. The major differences between test and control diets were an increased amount of vegetable protein (93% v 23% of total protein), of which 33 g/d was soy, and a doubling of soluble fiber. Fasting blood samples were obtained at the start and end of each phase. On the last 3 days of each phase, fecal collections were obtained. Compared with the low-fat control diet, the test diet decreased total cholesterol (6.2% +/- 1.2%, P < .001), low-density lipoprotein (LDL) cholesterol (6.7% +/- 1.7%, P < .001), apolipoprotein B (8.2% +/- 1.2%, P < .001), and the ratios of LDL to high-density lipoprotein (HDL) cholesterol (6.3% +/- 2.0%, P = .004) and apolipoprotein B to A-I (5.4% +/- 1.5%, P = .001). A combination of vegetable protein and soluble fiber significantly improved the lipid-lowering effect of a low-saturated-fat diet. The results support expanding the current dietary advice to include increased vegetable protein and soluble fiber intake so that the gap in effectiveness between a good diet and drug therapy is reduced.

Source : Pubmed