Cytotoxicity and lipid peroxidation-inhibiting activity of flavonoids

Auteur(s) :
Calomme M., Cimanga K., Costanzo PR., De Bruyne T., Pieters L., Sindambiwe JB., Vanden Berghe D., Vlietinck AJ.
Date :
Août, 2001
Source(s) :
PLANTA MEDICA. #67:6 p515-519
Adresse :
"VANDEN BERGHE D,UNIV INSTELLING ANTWERP,DEPT PHARMACEUT SCI;UNIV PL 1;B-2610 WILRIJK, BELGIUM.microfar@uia.ua.ac.be "

Sommaire de l'article

Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship was established. Subsequently, an antioxidant selectivity index, i.e., the maximal non-toxic dose divided by the IC50 value for lipid peroxidation, was introduced. Kaempferol showed the highest antioxidant selectivity index of all flavonoids tested.

Source : Pubmed
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