Dietary intakes of citrus fruit and risk of gastric cancer incidence: an adaptive meta-analysis of cohort studies.

Auteur(s) :
Bae JM., Kim EH.
Date :
Juil, 2016
Source(s) :
Epidemiology and health. #: p
Adresse :
Jeju National University School of Medicine, Jeju, Korea. [email protected]

Sommaire de l'article
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Purpose
Under the situation that antioxidant supplementary has no anticancer effect, updating meta-analysis to evaluate association between intake of citrus fruit and gastric cancer risk.

Methods
The list of articles to be searched was established using citation discovery tools provided by PubMed and Scopus. The effect size of each article to be used in meta-analysis was calculated using interval-collapse method. Summary effect size (sES) and 95% confidence intervals (CI) were obtained by conducting meta-analysis. Random effect dose-response meta-regression (DRMR) was performed to investigate the dose-response relationship.

Results
A total of 5 cohort studies were selected. The result was 13% reduction of gastric cancer according to the intake of citrus fruit (sES=0.87, 95% CI: 0.76-0.99, I-squared = 69.6%). In sub-group analysis, it was found that the intake of citrus fruit inhibited cardia gastric cancer (CGC) (sES= 0.67, 95% CI: 0.55-0.81, I-squared=46.1%) and as a result of DRMR, 100 gram citrus fruit intake per day inhibits CGC by 40% (RR=0.60, 95% CI: 0.44-0.83).

Conclusions
It is suggested that the intake of citrus fruit inhibits the development of CGC. This conclusion can be used as a primary prevention measures in the future under the situation that the incidence of CGC tends to increase currently.

Source : Pubmed
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