Early introduction of root vegetables in infancy associated with advanced ß-cell autoimmunity in young children with human leukocyte antigen-conferred susceptibility to type 1 diabetes.

Auteur(s) :
Virtanen SM., Takkinen HM., Nevalainen J.
Date :
Mar, 2011
Source(s) :
DIABET MED.. # p
Adresse :
Department of Lifestyle and Participation, Nutrition Unit, National Institute for Health and Welfare, Helsinki Tampere School of Public Health, University of Tampere Tampere University Hospital Research Unit, Tampere, §Department of Statistics, University of Turku, Turku, Finland Department of Epidemiology and Population Health, Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK Department of Nutrition, University of Helsinki, Helsinki Department of Paediatrics, University of Oulu, Oulu Department of Paediatrics, §§Department of Virology, University of Turku, Turku Department of Virology, University of Eastern Finland, Kuopio Department of Paediatrics, Tampere University Hospital, Tampere Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.

Sommaire de l'article

Aims
Early introduction of supplementary foods has been implicated to play a role in the development of ß-cell autoimmunity. We set out to study the effects of breastfeeding and age at introduction of supplementary foods on the development of ß-cell autoimmunity.

Methods 
A prospective birth cohort of 6069 infants with HLA-DQb-conferred susceptibility to Type 1 diabetes was recruited between 1996 and 2004. Antibodies against islet cells, insulin, glutamate dehydroxylase and islet antigen 2 were measured at 3- to 12-month intervals. The families recorded at home the age at introduction of new foods and, for each visit, completed a structured dietary questionnaire. The endpoint was repeated positivity for islet cell antibodies plus at least one other antibody and/or clinical Type 1 diabetes (n = 265).

Results
Early introduction of root vegetables (by the age of 4 months) was related to increased risk of developing positivity for the endpoint [hazard ratio (95% CI) for the earliest third 1.75 (1.11-2.75) and for the middle third 1.79 (1.22-2.62) compared with the last third (> 4 months), likelihood ratio test P = 0.006], independently of the introduction of other foods and of several putative socio-demographic and perinatal confounding factors. Introducing wheat, rye, oats and/or barley cereals (P = 0.013) and egg (P = 0.031) early was related to an increased risk of the endpoint, but only during the first 3 years of life. Conclusions  Early introduction of root vegetables during infancy is independently associated with increased risk of ß-cell autoimmunity among Finnish children with increased genetic susceptibility to Type 1 diabetes.

Source : Pubmed
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