Effects of a diet high in plant sterols, vegetable proteins, and viscous fibers (dietary portfolio) on circulating sterol levels and red cell fragility in hypercholesterolemic subjects

Auteur(s) :
Vidgen E., Connelly PW., Cunnane SC., Jones PJ., Jenkins DJA., Kendall CWC., Lapsley KG., Marchie A., Trautwein EA., Raeini-sarjaz M.
Date :
Fév, 2005
Source(s) :
LIPIDS. #40:2 p169-174
Adresse :
Reprints: JENKINS DJA,ST MICHAELS HOSP,CLIN NUTR & RISK FACTOR MODIFICAT CTR;61 QUEEN ST E;M5C 2T2 TORONTO ON, CANADA. cyril.kendall@utoronto.ca Research Institutions: St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON M5C 2T2, Canada. St Michaels Hosp, Dept Med, Div Endocrinol & Metab, Toronto, ON M5C 2T2, Canada. McGill Univ, Sch Dietet & Human Nutr, Montreal, PQ, Canada. Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada. Univ Toronto, Dept Med, Toronto, ON M5S 3E2, Canada. Univ Toronto, Dept Biochem, Toronto, ON M5S 3E2, Canada. Univ Toronto, Dept Lab Med & Pathobiol, Fac Med, Toronto, ON M5S 3E2, Canada. Unilever Hlth Inst, Unilever R&D, Vlaardingen, Netherlands. Almond Board Calif, Modesto, CA 95354 USA. Discipline: BIOCHEMISTRY & BIOPHYSICS AGRICULTURAL CHEMISTRY

Sommaire de l'article

Plant sterols, soy proteins, viscous fibers, and nuts are advised for cholesterol reduction, but their combined effect on plant sterol absorption has never been tested. We assessed their combined action on serum sterols in hyperlipidemic subjects who were following low-saturated fat diets before starting the study and who returned to these diets post-test. The 1-mon test (combination) diet was high in plant sterols (1 g/1,000 kcal), soy protein (23 g/1,000 kcal), viscous fiber (9 g/1,000 kcal), and almonds (14 g/1 000 kcal). Fasting blood was obtained for serum lipids and sterols, and erythrocytes were obtained for fragility prior to and at 2-wk intervals during the study. The combination diet raised serum campesterol concentrations by 50% and beta-sitosterol by 27%, although these changes were not significant after Bonferroni correction; near-maximal rises were found by the end of the first week, but no change was found in red cell fragility despite a 29% reduction in the LDL cholesterol level. No significant associations were observed between changes in red cell fragility and blood lipids or sterols. We conclude that plant sterols had a minimal impact on serum sterol concentrations or red cell fragility in hyperlipidemic subjects on diets that greatly reduced their serum lipids.

Source : Pubmed