Effects of genetic and nutritional factors on bone mineral density in young adults.

Auteur(s) :
Sakaguchi K., Otsuki T., Hatta E., Hatayama T., Hatada S., Miura Y., Takata-tomokuni A., Hyodoh F., Tomomitsu T., Fukunaga M., Katsuyama H.
Date :
Oct, 2004
Source(s) :
Adresse :
Department of Hygiene, Kawasaki Medical School, Kurashiki 701-0192, Japan. takemi@med.kawasaki-m.ac.jp

Sommaire de l'article

To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucleotide polymorphisms (SNPs) for vitamin (Vit) D receptor (VDR), estrogen receptor alpha (ERalpha), interleukin 1 receptor antagonist (IL1RA), and apolipoprotein E (ApoE) genes. Daily intakes of Vit C, fiber, soybean and related foods, and green and yellow vegetables showed a correlation with % BMD. In addition, Vit B2 as well as Vit C, and vegetables were identified as important factors for BMD by Stepwise regression analysis. Among the SNPs analyzed, the B+ type of the VDR gene tended to be associated with a lower BMD, and pp type of the ER gene digested by the PvuII enzyme in females indicated a significantly lower BMD than that in males. In addition, these SNPs were also identified by factor analysis to be associated with BMD. These results suggested that a complex array of genetic factors, such as two or more SNPs or SNPs and gender, may be important to BMD.

Source : Pubmed