Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris).

Auteur(s) :
Mendez MA., Sunyer J., Haugen M., Alexander J., Meltzer HM., Chatzi L., Kogevinas M., Pedersen M., Schoket B., Godschalk RW., Espinosa A., Landström A., Villanueva CM., Merlo DF., Fthenou E., Gracia-Lavedan E., van Schooten FJ., Hoek G., Brunborg G., Nielsen JK., Wright J., Kovács K., de Hoogh K., Gutzkow KB., Hardie LJ., Knudsen LE., Anna L., Ketzel M., Botsivali M., Nieuwenhuijsen MJ., Cirach M., Toledano MB., Smith RB., Fleming S., Agramunt S., Kyrtopoulos SA., Lukács V., Segerbäck D.
Date :
Avr, 2015
Source(s) :
Environmental health perspectives. #123:4 p374-80
Adresse :
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Universitat Pompeu Fabra, Barcelona, Spain; and INSERM (National Institute of Health and Medical Research), U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute Albert Bonniot, Grenoble, France. [email protected]

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BACKGROUND
Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birthweight and may predict cancer risk.

AIM
We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates.

METHODS
Pregnant women from Greece, Spain, England, Denmark and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the (32)P-postlabelling technique (n=511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs) were available for a large proportion of the study population.

RESULTS
Greek and Spanish neonates had higher adduct levels than the Northern European neonates (median: 12.1 (n=179) vs. 6.8 (n=332) adducts per 10(8) nucleotides, p<0.001). Being from the Southern European countries, higher maternal body mass-index, delivery by Caesarean section, being boy, low maternal intake of fruits rich in vitamin C, high intake of dairy products and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Air pollution exposure to PM2.5 and NO2 was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.

CONCLUSIONS
These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.

Source : Pubmed
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