Fruit and vegetable consumption and risk of epithelial ovarian cancer: the european prospective investigation into cancer and nutrition

Title:
Author(s): Schulz M, Lahmann PH, Boeing H, Hoffmann K, Allen N, Key TJA, Bingham S, Wirfalt E, Berglund G, Lundin E, Hallmans G, Lukanova A, Garcia CM, Gonzalez CA, Tormo MJ, Quiros JR, Ardanaz E, Larranaga N, Lund E, Gram IT, Skeie G, Peeters PHM, van Gils CH, Bueno-de-Mesquita HB, Buchner FL, Pasanisi P, Galasso R, Palli D, Tumino R, Vineis P, Trichopoulou A, Kalapothaki V, Trichopoulos D, Chang-Claude J, Linseisen J, Boutron-Ruault MC, Touillaud M, Clavel-Chapelon F, Olsen A, Tjonneland A, Overvad K, Tetsche M, Jenab M, Norat T, Kaaks R, Riboli E
Source: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 14 (11): 2531-2535 Part 1 NOV 2005
Document Type: Article
Language: English
Abstract: Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view.
Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done.

Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk.

Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.

KeyWords Plus: ALLIUM VEGETABLES; DIETARY FACTORS; FOOD GROUPS; DETERMINANTS; MORTALITY; CAROTENOIDS; NUTRIENTS; COUNTRIES; COHORT
Addresses: Schulz M (reprint author), German Inst Human Nutr, Dept Epidemiol, Potsdam Rehbrucke,Arthur Scheunert Allee 114-116, D-14458 Nuthetal Germany
German Inst Human Nutr, Dept Epidemiol, D-14458 Nuthetal Germany
Univ Oxford, Canc Res UK, Epidemiol Unit, Oxford OX1 2JD England
MRC, Dunn Nutr Unit, Cambridge CB4 1XJ England
Lund Univ, Malmo Univ Hosp, Dept Med, S-22100 Lund Sweden
Umea Univ, Dept Biomed Sci Pathol, S-90187 Umea Sweden
Umea Univ, Dept Publ Hlth, S-90187 Umea Sweden
Umea Univ, Dept Clin Med Nutrit Res, S-90187 Umea Sweden
NYU, Dept Obstet & Gynecol Epidemiol, New York, NY USA
Andalusian Sch Publ Hlht, Granada, Spain
Catalan Inst Oncol, Dept Epidemiol, Barcelona, Spain
Hlth Council Murcia, Dept Epidemiol, Murcia, Spain
Publ Hlth & Hlth Planning Directorate, Asturias, Spain
Inst Publ Hlth, Navarra, Spain
Dept Publ Hlth Guipuzkoa, San Sebastian, Spain
Univ Tromso, Inst Community Med, Dept Prevent Med, N-9001 Tromso Norway
Univ Utrecht, Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven Netherlands
Ist Nazl Tumori, Dept Prevent & Predict Med, I-20133 Milan Italy
Osped Oncol Reg, Vulture, Italy
Sci Inst Tuscany, Ctr Canc Res & Prevent, Mol & Nutrit Epidemiol Unit, Florence, Italy
Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy
Univ Turin, Canc Epidemiol Unit, I-10124 Turin Italy
Univ London Imperial Coll Sci & Technol, London, England
Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-10679 Athens Greece
German Canc Res Ctr, D-6900 Heidelberg Germany
Inst Gustave Roussy, INSERM, U521, F-94805 Villejuif France
Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark
Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark
IARC, Lyon, France
E-mail Addresses: [email protected]

Publisher: AMER ASSOC CANCER RESEARCH, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA, http://www.aacr.org
Discipline: ONCOLOGY