Geraniol, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells

Auteur(s) :
Carnesecchi S., Ceraline J., Duranton B., Gosse F., Raul F., Schneider Y., Seiler N.
Date :
Juil, 2001
Source(s) :
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. #298:1 p197-200
Adresse :
"RAUL F,IRCAD,LAB NUTR CHEMOPREVENT DIGEST ONCOL;1 PL HOP,BP 426;F-67091 STRASBOURG, FRANCE.francis.raul@ircad.u-strasbg.fr"

Sommaire de l'article

Geraniol and other monoterpenes found in essential oils of fruits and herbs have been suggested to represent a new class of agents for cancer chemoprevention. As a first step in clarifying the mode of action of geraniol on colon carcinogenesis, we studied its effects on the growth of a human colon cancer cell line (Caco-2). Geraniol (400 muM) caused a 70% inhibition of cell growth, with cells accumulating in the S transition phase of the cell cycle, and concomitant inhibition of DNA synthesis. No signs of cytotoxicity or apoptosis were detected. Geraniol caused a 50% decrease of ornithine decarboxylase activity, a key enzyme of polyamine biosynthesis, which is enhanced in cancer growth. This led to a 40% reduction of the intracellular pool of putrescine. Geraniol also activated the intracellular catabolism of polyamines, indicated by enhanced polyamine acetylation. These observations indicate that polyamine metabolism is presumably a target in the antiproliferative properties of geraniol.

Source : Pubmed
Retour