Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate

Auteur(s) :
Capelozzi VL., Di Mascio P., Gomes OF., Matos HR., Medeiros MHG.
Date :
Déc, 2001
Source(s) :
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. #396:2 p171-177
Adresse :
"MEDEIROS MHG,UNIV SAO PAULO,INST QUIM DEPT BIOQUIM;CP 26077;BR-05513970 SAO PAULO, BRAZIL.mhgdmede@iq.usp.br "

Sommaire de l'article

Experimental and epidemiological evidence suggests that lycopene, a carotenoid present in tomatoes, tomato products, and several fruits and vegetables, may play a role in preventing certain cancers in humans. We have investigated the effect of lycopene pretreatment on lipid peroxidation, oxidative damage to DNA, and histopathological changes in liver of animals subjected to intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) administration. Compared with control rats, liver of Fe-NTA-treated animals showed a significant increase in the 8-oxo-7,8-dihydro-2'-deoxy-guanosine level and a 75% increase in malondialdehyde accumulation concomitant with histopathological changes. Five days of lycopene pretreatment (10 mg/kg body weight, ip) almost completely prevented liver biomolecule oxidative damage and protected the tissue against the observed histological alterations.

Source : Pubmed
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