Maternal dietary risk factors in childhood acute lymphoblastic leukemia (united states).

Auteur(s) :
Block G., Ma X., Jensen CD., Buffler P., Selvin S., Month S.
Date :
Août, 2004
Source(s) :
Cancer causes & control : CCC. #15:6 p559-570
Adresse :
School of Public Health, 419 Warren Hall, University of California, Berkeley, CA 94720-7360, USA. Ph.: +1-510-643-1875; Fax: +1-510-643-6981; E-mail:

Sommaire de l'article

Objective : Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and the second most common cause of mortality in children aged 1-14 years. Recent research has established that the disease can originate in utero, and thus maternal diet may be an important risk factor for ALL. Methods : The Northern California Childhood Leukemia Study is a population-based case-control study of risk factors for childhood leukemia, including maternal diet. Cases (n = 138) and controls (n = 138) were matched on sex, date of birth, mother’s race, Hispanicity, and county of residence at birth. Maternal dietary intake in the 12months prior to pregnancy was obtained by a 76-item food frequency questionnaire. Results : Consumption of the vegetables (OR = 0.53; 95% CI, 0.33-0.85; p = 0.008), protein sources (OR = 0.40; 95% CI, 0.18-0.90, p = 0.03), and fruits (OR = 0.71; 95% CI, 0.49-1.04; p = 0.08) food groups were inversely associated with ALL. Among nutrients, consumption of provitamin A carotenoids (OR = 0.65, 95% CI, 0.42-1.01; p = 0.05), and the antioxidant glutathione (OR = 0.42; 95% CI, 0.16-1.10; p = 0.08) were inversely associated with ALL. Conclusion : Maternal dietary factors, specifically the consumption of vegetables, fruits, protein sources and related nutrients, may play a role in the etiology of ALL. Dietary carotenoids and glutathione appear to be important contributors to this effect.

Source : Pubmed