Microsatellite polymorphisms in the epidermal growth factor receptor (egfr) gene and the transforming growth factor-alpha (tgfa) gene and risk of oral cancer in puerto rico.

Auteur(s) :
Gridley G., Diehl SR., Hayes RB., Engel LS., Kang D., Huang WY., Winn DM., Browning LM., Bravo-otero E., Wu HT.
Date :
Mai, 2005
Source(s) :
Adresse :
aDepartment of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, SNUCM, Seoul, Korea bDivision of Cancer Epidemiology and Genetics cDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, USA dDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA eUniversity of Puerto Rico, San Juan, Puerto Rico fCraniofacial Epidemiology and Genetics Branch, NIDCR, Bethesda, MD, USA.

Sommaire de l'article

OBJECTIVES AND METHODS: Risks of oral cancer related to a CA microsatellite repeat polymorphism in intron 1 of the epidermal growth factor receptor (EGFR) gene and a TaqI polymorphism in the transforming growth factor-alpha (TGFA) gene were evaluated in a population-based case-control study consisting of 157 cases and 149 controls recruited in Puerto Rico. RESULTS: Carriers of >/=16 CA repeats in EGFR showed a 1.9-fold increased risk for oral cancer (OR=1.9, 95% CI=1.0-3.5). Risks also tended to increase with decreasing number of alleles with >/=16 CA repeats (P for trend=0.06). Our data suggested a non-significant reduction in risk for subjects heterozygous for the TGFA polymorphism (OR=0.6, 95% CI=0.2-1.3). CONCLUSIONS: The EGFR-associated risk appeared to be independent of tobacco and alcohol use and may be restricted primarily to subjects who consumed low amounts of fresh fruits and vegetables (OR=5.9, 95%CI: 2.3-15.2). These data implicate dietary and molecular targets for oral cancer prevention.

Source : Pubmed