Plant sterols and risk of stomach cancer: a case-control study in Uruguay

Auteur(s) :
De Stefani E., Deneo-Pellegrini H., Boffetta P., Mendilaharsu M., Brennan EP., Carzoglio JC., Ronco AL.
Date :
Fév, 2000
Source(s) :
Nutrition and cancer. #37:2 p140-144
Adresse :
Registro Nacional de Cancer, Montevideo, Uruguay.

Sommaire de l'article

In 1997-1999, 120 incident and histologically verified cases of stomach cancer were frequency matched on age, gender, residence, and urban/rural status with 360 controls to study the role of diet in gastric cancer in Uruguay. We focused on the role of plant sterols (beta-sitosterol, campesterol, stigmasterol, and total plant sterols) after controlling for major confounders. Total phytosterols were associated with a strong inverse relationship with stomach cancer (odds ratio of stomach cancer for total phytosterol intake in the highest tertile = 0.33, 95% confidence interval = 0.17-0.65). Joint exposure to high intake of total phytosterol and alpha-carotene was also inversely associated with gastric cancer risk (odds ratio = 0.09, 95% confidence interval = 0.02-0.32). High intake of total plant sterols explained most of the attenuation in risk of gastric cancer associated with vegetable and fruit intakes.

Source : Pubmed