Plasma antioxidant capacity of HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate containing antioxidant polyphenols

Auteur(s) :
Arendt BM., Berthold H., Boetzer AM., Goerlich R., Lemoch H., Rockstroh JK., Spengler U., Winkler P.
Date :
Sep, 2001
Source(s) :
European journal of clinical nutrition. #55:9 p786-792
Adresse :
"GOERLICH R,UNIV DUSSELDORF,SCH MED DEPT HEMOSTASIS & TRANSFUS MED;MOORENSTR 5;D-40225 DUSSELDORF, GERMANY."

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OBJECTIVE:
To investigate whether antioxidant polyphenols from fruit juices or a fruit-vegetable-concentrate increase the plasma antioxidant capacity in HIV-infected and healthy subjects.

DESIGN:
Twenty-three HIV-seropositive and 18 seronegative adults were randomized to ingest either 1 l of fruit juice or 30 ml fruit-vegetable-concentrate per day over 16 weeks in addition to their normal Western diet.

METHODS:
Plasma antioxidant capacity was determined as Trolox equivalent antioxidant capacity (TEAC) at baseline, after 1 and 16 weeks of intervention, and after a 6 week washout.

RESULTS:
There was no difference in plasma antioxidant capacity between HIV-infected and healthy subjects at baseline (P=0.1). After 16 weeks of intervention TEAC increased in HIV-positive subjects with both types of polyphenol supplementation (juice, 1.38+/-0.07 to 1.42+/-0.04 mM, P=0.034; concentrate, 1.40+/-0.09 to 1.46+/-0.08 mM, P=0.025). TEAC was not altered by either type of supplementation in HIV-seronegative subjects.

CONCLUSION:
Plasma antioxidant capacity can be increased by long-term ingestion of polyphenols from fruit juices or fruit-vegetable-concentrate in HIV-seropositive but not in HIV-seronegative subjects.

SPONSORSHIP:
This study was supported by a grant and Cellagon aurum from HG Berner GmbH, Altenholz, and fruit juices from Eckes Granini GmbH & Co. KG, Nieder-Olm.

Source : Pubmed
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