Two novel cucurbitacins, neocucurbitacins A and B, from the Brazilian folk medicine « Buchinha » (Luffa operculata) and their effect on PEBP2alphaA and OCIF gene expression in a human osteoblast-like Saos-2 cell line.

Auteur(s) :
Hakamatsuka T., Kawahara N., Satake M., Sekita S., Kurata A.
Date :
Oct, 2001
Source(s) :
CHEMICAL AND PHARMACEUTICAL BULLETIN. #49:10 p1377-1379
Adresse :
KAWAHARA N,NATL INST HLTH SCI,SETAGAYA KU;1-18-1 KAMIYOGA; TOKYO 1588501, JAPAN.kawahara@nihs.go.jp

Sommaire de l'article

Two novel cucurbitacins designated as neocucurbitacins A (1), possessing inhibitory activity of polyoma enhancer binding protein 2 alphaA (PEBP2 alphaA) and osteoclastogenesis-inhibitory factor (OCIF) gene expression in human osteoblast-like cells, and B (2) were isolated from the fruit of Luffa operculata. Their structures have been determined by extensive spectroscopic investigation.

Source : Pubmed
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