Cranberry and its phytochemicals: a review of in vitro anticancer studies

Auteur(s) :
Neto CC.
Date :
Jan, 2007
Source(s) :
JOURNAL OF NUTRITION. #137:1 p186S-193S
Adresse :
Neto CC (reprint author), Univ Massachusetts Dartmouth, Dept Chem & Biochem, N Dartmouth, MA 02747 USA Univ Massachusetts Dartmouth, Dept Chem & Biochem, N Dartmouth, MA 02747 USA E-mail Addresses: cneto@umassd.edu Publisher: AMER SOCIETY NUTRITIONAL SCIENCE, 9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA, http://www.nutrition.org Discipline: FOOD SCIENCE/NUTRITION

Sommaire de l'article

Abstract: This article reviews the existing research on the anticancer properties of cranberry fruit and key phytochemicals that are likely contributors to chemoprevention. Results from in vitro studies using a variety of tumor models show that polyphenolic extracts from Vaccinium macrocarpon inhibit the growth and proliferation of breast, colon, prostate, lung, and other tumors, as do flavonols, proanthocyanidin oligomers, and triterpenoids isolated from the fruit. The unique combination of phytochemicals found in cranberry fruit may produce synergistic health benefits. Possible chemopreventive mechanisms of action by cranberry phytochemicals include induction of apoptosis in tumor cells, reduced ornithine decarboxylase activity, decreased expression of matrix metalloproteinases associated with prostate tumor metastasis, and antiinflammatory activities including inhibition of cyclooxygenases. These findings suggest a potential role for cranberry as a dietary chemopreventive and provide direction for future research.
KeyWords Plus: FRUIT VACCINIUM-MACROCARPON; BREAST-CANCER CELLS; GRAPE SEED PROANTHOCYANIDINS; FIMBRIATED ESCHERICHIA-COLI; ANTI-ANGIOGENIC PROPERTY; URSOLIC ACID; ANTIINFLAMMATORY ACTIVITY; CYCLE ARREST; CYCLOOXYGENASE-2 TRANSCRIPTION; ORNITHINE-DECARBOXYLASE

Source : Pubmed
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