Glutathione transferases, broccoli, and colon adenomas

Auteur(s) :
Frankl HD., Haile RW., Lee ER., Dai AH., Huang HF., Lin HJ., Zhou HY.
Date :
Fév, 2001
Source(s) :
CHEMICO-BIOLOGICAL INTERACTIONS. #133:1-3 p81-83
Adresse :
LIN HJ,UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR DIV MED GENET;1124 W CARSON ST; TORRANCE CA 90502, USA.henry_lin@humc.edu

Sommaire de l'article

Our interest is to use an epidemiologic approach to study how cruciferous vegetables may prevent colorectal adenomas, which are precursors to cancer. Broccoli contains the compound, sulforaphane, an isothiocyanate that induces carcinogen-detoxifying enzymes. Isothiocyanates are conjugated by glutathione transferase enzymes, leading to excretion. In an earlier case-control study, we observed the lowest prevalence of colorectal adenomas among subjects with high broccoli intake and the GSTM1 null genotype. Here we extend the analysis to a genetic variant of GSTP1.

Source : Pubmed
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