Low levels of carotenoids and retinol in involutional osteoporosis.

Auteur(s) :
Stahl W., Polidori MC., Cherubini A., Ruggiero C., Maggio D., Barabani M., Tufi A., Cecchetti R., Aisa MC.
Date :
Fév, 2006
Source(s) :
BONE. #38:2 p244-8
Adresse :
Institute of Gerontology and Geriatrics, University of Perugia, Policlinico Monteluce, Via Brunamonti, 06124 Perugia, Italy.

Sommaire de l'article

Previous epidemiological studies conducted in retinol-supplemented subjects showed an association between high serum levels or dietary intake of retinol and risk of hip fracture. On the other side, observational studies revealed that non-supplemented subjects with higher dietary intake of retinol lose less bone with age than subjects with lower intake. This discrepancy, currently unexplained, suggests that nutrition plays a major role in conditioning the effects of retinol on bone. Since retinol is derived from both retinoids – contained in animal food – and carotenoids – contained in vegetables and fruits – we evaluated a possible role of carotenoids in involutional osteoporosis. Therefore, plasma levels of beta-carotene and other carotenoids, in addition to those of retinol, were measured in free-living, non-supplemented, elderly women with or without severe osteoporosis. Plasma levels of retinol and of all carotenoids tested, with the exception of lutein, were consistently lower in osteoporotic than in control women. A weak association was found only between retinol and femoral neck bone mineral density in osteoporotic women. Our study suggests a bone sparing effect of retinol, to which the provitamin A activity of some carotenoids might have contributed.

Source : Pubmed