Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study.

Auteur(s) :
Sun Q., Fung TT., Hu FB., Rexrode KM., Crous-Bou M., Prescott J., Julin B., Du M., De Vivo I.
Date :
Déc, 2014
Source(s) :
BMJ. #349: pg6674
Adresse :
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA School of Public Health, University of Washington, Seattle, WA 98195, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [email protected]

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OBJECTIVE
To examine whether adherence to the Mediterranean diet was associated with longer telomere length, a biomarker of aging.

DESIGN
Population based cohort study.

SETTING
Nurses' Health Study, an ongoing prospective cohort study of 121?700 nurses enrolled in 1976; in 1989-90 a subset of 32?825 women provided blood samples.

PARTICIPANTS
4676 disease-free women from nested case-control studies within the Nurses' Health Study with telomere length measured who also completed food frequency questionnaires.

MAIN OUTCOME MEASURE
Association between relative telomere lengths in peripheral blood leukocytes measured by quantitative real time polymerase chain reaction and Alternate Mediterranean Diet score calculated from self reported dietary data.

RESULTS
Greater adherence to the Mediterranean diet was associated with longer telomeres after adjustment for potential confounders. Least squares mean telomere length z scores were -0.038 (SE 0.035) for the lowest Mediterranean diet score groups and 0.072 (0.030) for the highest group (P for trend=0.004).

CONCLUSION
In this large study, greater adherence to the Mediterranean diet was associated with longer telomeres. These results further support the benefits of adherence to the Mediterranean diet for promoting health and longevity.

Source : Pubmed
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