Organochlorine insecticides in substantia nigra in Parkinson’s disease

Auteur(s) :
Corrigan FM., Daniel SE., Mannino DM., Shore RF., Wienburg CL.
Date :
Fév, 2000
Source(s) :
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. #59:4 p229-234
Adresse :
"CORRIGAN FM,ARGYLL & BUTE HOSP,LOMOND & ARGYLL PRIMARY CARE TRUST;LOCHGILPHEAD PA31 8LD,ARGYLL SCOTLAND.fmcorrigan@aol.com"

Sommaire de l'article

The concentrations of organochlorine (OC) compounds in the substantia nigra (SN) were compared in Parkinson's disease (PD) with concentrations in brain from cortical Lewy body dementia (CLBD), Alzheimer's disease (AD), and nondemented nonparkinsonian controls (CON). The levels of the gamma isomer of hexachlorocyclohexane (gamma HCH, lindane) were significantly higher in PD tissues (mean +/- SD: 0.56 +/- 0.434 mu g/g lipid) than in the other three groups (CLBD 0.052 +/- 0. 101 mu g/g lipid; AD none detected; CON 0.125 +/- 0.195: all differences from PD significant at p < .05, Mann-Whitney U-test). Dieldrin (HEOD) was higher in PD brain than in AD or control brain, while 1, 1'-(2,2-dichloroethenyl diene)-bis(4-chlorobenzene) (p,p-DDE) and total Aroclor-matched polychlorinated biphenyls (matched PCBs) were only higher in PD substantia nigra when these concentrations were compared with those of CLBD. These findings are not inconsistent with the hypothesis derived from epidemiological work and animal studies that organochlorine insecticides produce a direct toxic action on the dopaminergic tracts of the substantia nigra and may contribute to the development of PD in those rendered susceptible by virtue of cytochrome P-450 polymorphism, excessive exposure, or other factors.

Source : Pubmed
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