Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer.

Auteur(s) :
Darband SG., Kaviani M., Yousefi B., Sadighparvar S., Pakdel FG., Attari JA., Mohebbi I., Naderi S., Majidinia M.
Date :
Sep, 2018
Source(s) :
Journal of cellular physiology. #233:9 p6544-6560
Adresse :
Danesh Pey Hadi Co., Health Technology, Development Center, Urmia University of Medical Sciences, Urmia, Iran.

Sommaire de l'article

Recently, an intense attention has been paid to the application of natural compounds as a novel therapeutic strategy for cancer treatment. Quercetin, a natural flavonol present in many commonly consumed food items, is widely demonstrated to exert inhibitory effects on cancer progression through various mechanisms. Since there is a strong association with diets containing abundant vegetables, fruits, and grains, and significant decline in the risk of colon cancer, accumulation studies have focused on the anticancer potential of quercetin in colorectal cancer. Cell cycle arrest, increase in apoptosis, antioxidant replication, modulation of estrogen receptors, regulation of signaling pathways, inhibition of and metastasis and angiogenesis are among various mechanisms underlying the chemo-preventive effects of quercetin in colorectal cancer. This review covers various therapeutic interactions of Quercetin as to how targets cellular involved in cancer treatment.

Source : Pubmed