Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder.

Auteur(s) :
Pearson DA., Rahbar MH., Lee M., Samms-Vaughan M., Dickerson AS., Loveland KA., Ardjomand-Hessabi M., Bressler J., Shakespeare-Pellington S., Grove ML., Boerwinkle E.
Date :
Sep, 2014
Source(s) :
Res Autism Spectr Disord.. #8:9 p1134-1145
Adresse :
Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, and Division of Clinical and Translational Sciences, Department of Internal Medicine, Medical School, and Biostatistics/Epidemiology/Research Design (BERD) Core, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, Texas 77030, USA

Sommaire de l'article

Human exposure to cadmium has adverse effects on the nervous system. Utilizing data from 110 age- and sex-matched case-control pairs (220 children) ages 2-8 years in Kingston, Jamaica, we compared the 75th percentile of blood cadmium concentrations in children with and without Autism Spectrum Disorder (ASD). In both univariable and multivariable Quantile Regression Models that controlled for potential confounding factors, we did not find any significant differences between ASD cases and typically developing (TD) controls with respect to the 75th percentile of blood cadmium concentrations, (P > 0.22). However, we found a significantly higher 75th percentile of blood cadmium concentrations in TD Jamaican children who consumed shellfish (lobsters, crabs) (P <0.05), fried plantain (P <0.01), and boiled dumpling (P <0.01). We also observed that children living in Jamaica have an arithmetic mean blood cadmium concentration of 0.16μg/L which is similar to that of the children in developed countries and much lower than that of children in developing countries. Although our results do not support an association between blood cadmium concentrations and ASD, to our knowledge, this study is the first to report levels of blood cadmium in TD children as well as those with ASD in Jamaica.

Source : Pubmed