The medi-rivage study: reduction of cardiovascular disease risk factors after a 3-mo intervention with a mediterranean-type diet or a low-fat diet.

Auteur(s) :
Verger P., Gerber M., Lairon D., Grolier P., Bernard MC., Defoort C., Portugal H., Planells R., Amiot-carlin MJ., Vague P., Vincent-baudry S., Helal O.
Date :
Nov, 2005
Source(s) :
Adresse :
Human Nutrition and Lipids Joint Research Unit 476-INSERM, National Institute of Health and Medical Research/1260-National Institute of Agronomic Research, Faculty of Medicine Timone, Universite de la Mediterranee, Marseille, France.

Sommaire de l'article

BACKGROUND: Epidemiologic studies link Mediterranean-type diets to a low incidence of cardiovascular disease; however, few dietary intervention studies have been undertaken, especially in primary prevention.

OBJECTIVES: In the Mediterranean Diet, Cardiovascular Risks and Gene Polymorphisms (Medi-RIVAGE) study, the effects of a Mediterranean-type diet (Med group) or a low-fat diet (low-fat group) on risk factors were evaluated in 212 volunteers (men and women) with moderate risk factors for cardiovascular disease.

DESIGN: After the 3-mo dietary intervention, changes in many risk factors were evaluated. Dietary questionnaires and plasma nutritional markers were used to test compliance.

ESULTS: Although the dietary goals were only partially reached, changes in dietary habits were observed in both groups (n = 169): protein, carbohydrate, and fiber intakes increased and fat quality (decreased saturated fat and increased monounsaturated or polyunsaturated fat) improved. BMI, total and triacylglycerol-rich lipoprotein (TRL) cholesterol, triacylglycerols, TRL triacylglycerols, apolipoproteins A-I and B, insulinemia, glycemia, and the homeostasis model assessment score were significantly lower after 3 mo. The reductions in total cholesterol, triacylglycerols, and insulinemia remained significant after adjustment for BMI. There was a trend for a diet-by-time interaction for LDL cholesterol (P = 0.09). Our data predicted a 9% reduction in cardiovascular disease risk with the low-fat diet and a 15% reduction with this particular Mediterranean diet.

CONCLUSION: After a 3-mo intervention, both diets significantly reduced cardiovascular disease risk factors to an overall comparable extent.

Source : Pubmed